The sermon centers on the transformative conversion of Saul, later known as Paul, highlighting the radical shift from opposition to Christ to devoted obedience, illustrating that true spiritual change is not a matter of human will but divine renewal. It emphasizes that the natural human will, inherently opposed to God, cannot choose Him; instead, salvation is a work of God's grace, where the Spirit breaks and renews the heart, enabling a person to cry out, 'Lord, what wilt Thou have me to do?' The sermon draws a profound contrast between Paul's former self, driven by pride and persecution, and Christ's perfect obedience to the Father's will, which became His sustenance and joy. It calls believers to daily surrender their wills, discerning God's will through Scripture, a sensitive conscience, and providential circumstances, even amid suffering and uncertainty. Ultimately, the message affirms that walking in God's will—though often difficult—brings peace, purpose, and the assurance of being part of a divine plan, where every trial is shaped by the Father's love and the Son's sacrifice.