The sermon emphasizes the importance of practical holiness, rooted in God's will and accomplished through His grace, rather than legalistic adherence to rules. It clarifies that sanctification isn't about achieving perfection or progressive moral improvement, but a state of being set apart for God, initially established in eternity and ultimately fulfilled in Christ. The message underscores the necessity of avoiding sin, living a disciplined life, and maintaining dependence on God's Spirit, recognizing that true holiness stems from God's work within believers, leading to a continual growth in faith, love, and obedience, ultimately reflecting Christ's character.