What does the Bible say about Jesus being despised and rejected?

Isaiah 53:3 presents a profound characterization of the Messiah as 'despised and rejected of men.' This prophecy was fulfilled in Jesus, who demonstrated perfect virtue and goodness yet faced severe contempt from humanity. Throughout His ministry, Jesus' humble appearance and the simplicity of His message often led to His rejection—illustrating humanity's pride and depravity. The Jews, despite their knowledge of the Scriptures, chose to oversee the truth of His identity in favor of their own expectations and preconceived notions of the Messiah’s glory, ultimately preferring a criminal like Barabbas over Him (John 18:40). Thus, the rejection of Jesus underscores the deep-rooted spiritual blindness present in fallen humanity.