How do we know it's unwise to strive against God?

Romans 8:7 articulates that the carnal mind is hostility against God; such a mind cannot be subject to His law. This inherent enmity is rooted in our fallen nature, which causes us to resist and question God's authority. The warnings found in scripture, such as in Isaiah 45:9, serve to emphasize that contending with our Creator is not only foolish but can lead to disastrous consequences. The reality that God is sovereign over all creation is a key theological point, and understanding this helps us to recognize our place and limits as His creatures.