How do we know man is dead in trespasses and sins?

Romans 5:12 explicitly states that sin entered into the world through one man, Adam, and death through sin, meaning that all men have sinned and are spiritually dead because of this original sin. Genesis describes Adam's command from God, and his subsequent disobedience resulted in spiritual death—not merely a wound, but total death in trespasses and sins. This condition of spiritual deadness is universal, affecting all humanity, as expressed in Romans 3:10-23, where it is declared that there is none righteous, no, not one.