How does total depravity affect humanity?

Total depravity, a fundamental tenet of Reformed theology, teaches that as a result of the fall of Adam, every human being is born in sin and has a nature that is opposed to God. Scripture passages, such as Ephesians 2:1-3, illustrate that without divine intervention, humanity is dead in trespasses and sins, following the course of this world. This condition leaves individuals unable to turn to God or seek salvation on their own. The acknowledgment of total depravity highlights the necessity of God's sovereign grace to regenerate and give faith to the elect, who are spiritually dead apart from His intervention and mercy.