What does being spiritually dead mean?

Spiritual death, as described in Ephesians 2:1-3, indicates a condition of insensitivity to God's truth and an inability to seek Him without divine intervention. Jesus references this in John 5:25, where He speaks of the spiritually dead hearing His voice and coming to life. This concept highlights the total depravity of humanity; all are dead in their sins until quickened by God’s grace. It underscores the necessity of regeneration, which is the work of the Holy Spirit to awaken the sinner, enabling them to believe and respond to the Gospel.