What does the Bible say about being dead in trespasses and sins?

In Ephesians 2:1, the Apostle Paul teaches that people are dead in their trespasses and sins, signifying a state of spiritual deadness where one is unresponsive to God. This deadness is akin to physical death in that it renders one incapable of acknowledging or seeking God. Just as a physically dead person cannot see or hear, so too, a spiritually dead individual lacks the ability to perceive God's glory and righteousness, being blinded by sin and unbelief. Romans 1:21 further elaborates this point by emphasizing that when individuals knew God, they did not glorify Him, leading to a darkening of their hearts and minds, truly illustrating the depth of their spiritual death.