What does the Bible say about death by sin?

The condition of being dead in trespasses and sins is a central theme in scriptural teaching, emphasizing that all humanity is under the curse of death due to sin. Romans 5:12 reveals that through one man, sin entered into the world, and death by sin followed, spreading to all men. This state signifies a profound spiritual incapacity where individuals cannot cease from sin because they are spiritually dead. The pervasive nature of this death makes it impossible for humans to find favor with God through their own efforts, as discussed in Isaiah 64:6, which states that all our righteousnesses are like filthy rags.