What does the Bible say about man's spiritual condition?

According to Scripture, man's spiritual condition is one of total depravity, described in Romans 3:10-12 as 'none is righteous, no, not one.' This teaches that outside of Christ, humanity is spiritually dead, incapable of any good, and under the curse of sin, similar to lepers who are ostracized and without hope. Just as the lepers in 2 Kings 7 recognized their hopelessness, we must understand that without Christ, men exist in spiritual helplessness, unable to remedy their sinful state on their own. Jeremiah highlights this reality in Jeremiah 13:23, asking rhetorically how a leopard can change its spots, emphasizing the impossibility of a sinner transforming their nature without divine intervention.