What does the Bible say about prayer during times of trouble?

In moments of distress, the Bible emphasizes the importance of turning to God in prayer before seeking other forms of help. As seen in the accounts of Jacob pleading with God before confronting Esau and Hezekiah spreading Sennacherib's letter before the Lord, prayer is portrayed as the foremost remedy. Believers are encouraged to 'cast their burdens upon the Lord' (Psalm 55:22) and to make their requests known through prayer (Philippians 4:6) because none can relieve them as effectively as Christ can, who is both compassionate and willing to help in their time of need.