What does the Bible say about soul trouble?

Soul trouble, as detailed in John 12:27, reflects a profound internal distress that transcends mere physical suffering. The Lord Jesus exemplifies this in His own articulation of trouble regarding His impending crucifixion. In the Gospels, we see Him expressing the gravity of His soul's turmoil, particularly in the agonizing prayers at Gethsemane. This indicates a unique affliction that arises from the awareness of bearing the sins of His people and the resultant separation from God, prompting His plea for the Father's name to be glorified amidst His suffering. Thus, soul trouble is intricately linked to awareness of sin's weight and one's standing before God.