What does the Bible say about the spiritual condition of man?

In Matthew 9:31-34, the dumb man represents humanity's inability to speak to God due to sin. Just as this man was mute, sinners are spiritually dead and cannot express anything worthy before a holy God. As Brother Scott Richardson pointed out, God does not speak to or hear from any sinner outside of Christ. This reflects the biblical teaching that all men are born dead in trespasses and sins (Ephesians 2:1) and unable to call upon God and His mercy without the intervening grace of Jesus. Only through the power of God are we enabled to call out to Him, acknowledging our sinful state and seeking His mercy and grace.