What does the Bible say about the state of man by nature?

The scripture reveals the true condition of humanity, stating that all have sinned and fall short of the glory of God (Romans 3:23). David articulates this in Psalm 51:5, saying, 'Behold, I was shapen in iniquity; and in sin did my mother conceive me.' This underscores the inherent sinful nature of mankind, which cannot produce good in itself. The doctrine of total depravity explains that our natural state is one of spiritual darkness and rebellion against God, necessitating divine intervention for salvation.