What does total depravity mean in Christian theology?

Total depravity, as articulated in Reformed theology, means that every part of humanity—mind, will, emotions, and flesh—is corrupted by sin. This doctrine emphasizes that, as stated in Romans 3:10-12, 'there is none righteous, no, not one,' highlighting our complete inability to seek God or do good without divine intervention. The concept underscores the necessity of grace for salvation. Only by God's sovereign will and the regenerative work of the Holy Spirit can a sinner be brought to repentance and faith in Christ for salvation.