Why is it significant that Jesus was called a Nazarene?

Jesus being called a Nazarene is significant for various reasons. Firstly, it emphasizes his humble beginnings in a despised town, which serves as a critical part of his identity as the Messiah. This dismissal aligns with Isaiah 53:3, where it states he was 'despised and rejected by men.' Additionally, the label 'Nazarene' underscores how God often operates through what the world considers weak or insignificant. Such humility counters worldly expectations of power and prominence, pointing to God's sovereign grace in selecting unlikely vessels for his glory.