How do we know that Jesus' refusal to drink was significant?

The refusal of vinegar mingled with gall was significant as it illustrated Christ's mission and His willingness to experience the full extent of God's wrath for the sins of His people. As stated in Matthew 27:34, the drink was intended to mitigate pain, yet Jesus’ rejection underscores His purpose to fulfill the prophetic scriptures and embody the true suffering servant. His later acceptance of vinegar before His death symbolized the completion of His atoning work. He demonstrated that He would not abandon any part of His suffering until every requirement for redemption was fulfilled, epitomizing the essence of His sacrificial love and divine mission.