What does the Bible say about Jesus' anguish before his betrayal?

In John 13:21, we see Jesus expressing profound anguish as he reveals to his disciples that one of them will betray him. This moment not only emphasizes Jesus’ humanity but also his deep emotional connection to those he was closest to, demonstrating his understanding and foreknowledge of the suffering that was to come. This anguish was different from our usual anxieties; it stemmed from a holiness and deep love for his disciples, even for Judas, who would betray him. The passage reveals that Jesus was not taken by surprise, knowing fully the gravity of his situation and the fulfillment of Scripture regarding his suffering.